Protein Modification Reagents
Medchemexpress LLC Mal-PEG2-Val-Cit-PABA-PNP | 1345681-52-8 | 96.8% | 755.73 | C34H41N7O13 | 5 MG
Mal-PEG2-Val-Cit-PABA-PNP is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimide reactive group, a two-unit polyethylene glycol spacer, and a protease-sensitive Val-Cit-PABA peptide spacer that enables payload release in target cells.
- cleavable linker for ADC synthesis
- contains maleimide (Mal) reactive group
- two-unit PEG spacer (PEG2) provides solubility and flexibility
- val-cit-paba sequence is protease sensitive for intracellular release
- para-nitrophenyl (PNP) activating group for conjugation chemistry
- solid, white to off-white appearance; high purity
- available in multiple sizes and requires protection from light and storage under inert gas
eMolecules Mal-amido-PEG12-TFP ester | 1431295-77-0 | 250MG | Purity: 98%
Broadpharm | Mal-amido-PEG12-TFP ester | 250MG | 1431295-77-0 | MFCD27978401 | MW:82.39
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Medchemexpress LLC Pomalidomide-PEG6-C2-COOH | 2225148-49-0 | MFCD32173791 | 99.0% | C28H39N3O12 | 50 MG
Pomalidomide-PEG6-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a 6-unit PEG linker used in PROTAC technology. This product is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Pomalidomide based cereblon ligand
- Features a 6-unit PEG linker
- Used in PROTAC technology
- Pure form storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Shipping: Room temperature in continental US; may vary elsewhere
![eMolecules Broadpharm / N-(PEG1-acid)-L-Lysine-amido-Mal TFA salt / 100mg / 649280889 / BP-25721 / 98.000 / 2698339-21-6 / [null] / 412.443 / C18H28N4O7](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502480347.JPG-250.jpg)
eMolecules Broadpharm / N-(PEG1-acid)-L-Lysine-amido-Mal TFA salt / 100mg / 649280889 / BP-25721 / 98.000 / 2698339-21-6 / [null] / 412.443 / C18H28N4O7
Broadpharm / N-(PEG1-acid)-L-Lysine-amido-Mal TFA salt / 100mg / 649280889 / BP-25721 / 98.000 / 2698339-21-6 / [null] / 412.443 / C18H28N4O7
eMolecules Broadpharm / DBCO-NHCO-PEG4-acid / 25mg / 353441826 / BP-23760 / / 2110448-99-0 / MFCD31380393 / 552.624 / C30H36N2O8
Broadpharm / DBCO-NHCO-PEG4-acid / 25mg / 353441826 / BP-23760 / / 2110448-99-0 / MFCD31380393 / 552.624 / C30H36N2O8
Cayman Chemical VH 032 LInker 1 100mg
A PROTAC precursor; has been used in the synthesis of PROTACs targeting TEAD in cancer cells
Medchemexpress LLC DBCO-PEG4-Biotin | 1255942-07-4 | 99.5% | 100 MG
DBCO-PEG4-Biotin is an azadibenzocyclooctyne-biotin derivative that features a biotin group and four polyethylene glycol (PEG) units. This versatile biotinylation reagent is utilized for the introduction of a biotin moiety to azide-labeled biomolecules. It enables copper-free strain-promoted alkyne-azide click chemistry (SPAAC) reactions, leading to the formation of a stable triazole linkage.
- Contains a biotin group and four PEG units.
- Introduces a biotin moiety to azide-labeled biomolecules.
- Facilitates copper-free strain-promoted alkyne-azide click chemistry.
- Forms a stable triazole linkage.
- Utilized for research purposes.
Medchemexpress LLC Fmoc-NH-PEG11-CH2CH2COOH | 3076038-46-2 | 98.5% | 100 MG
Fmoc-NH-PEG11-CH2CH2COOH is a PEG-based PROTAC linker. It is primarily used in the synthesis of PROTACs, which are molecules designed to degrade target proteins by leveraging the intracellular ubiquitin-proteasome system. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Propargyl-PEG4-O-C1-NHS ester | 1161883-51-7 | 100 MG
Propargyl-PEG4-O-C1-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing azide groups.
- Target PROTAC linkers
- Part of the PROTAC pathway
- Functions as a click chemistry reagent
- Contains an alkyne group for copper-catalyzed azide-alkyne cycloaddition
- Used in the synthesis of PROTACs
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC DBCO-PEG3-Glu-VC-PABC-MMAF | 2253947-24-7 | 1 MG
DBCO-PEG3-Glu-VC-PABC-MMAF is a drug-linker conjugate for Antibody-Drug Conjugates (ADCs). It utilizes the tubulin inhibitor MMAF, linked via a cathepsin cleavable DBCO-PEG3-Glu-VC-PABC. This compound can be used in the synthesis of ADCs, which consist of an antibody to which an ADC cytotoxin is attached through an ADC linker.
- Drug-linker conjugate for Antibody-Drug Conjugates (ADCs)
- Uses tubulin inhibitor MMAF
- Linked via cathepsin cleavable DBCO-PEG3-Glu-VC-PABC
- Can be used in the synthesis of ADCs
- For research use only
Medchemexpress LLC Acid-C2-PEG4-C2-NHS ester | 1343476-41-4 | 98.0% | 50 MG
Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs, which consist of two distinct ligands connected by a linker. One ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. These PROTACs leverage the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- Molecular weight: 435.42
- Molecular formula: C18H29NO11
- Appears as a colorless to light yellow liquid
- Density: 1.30±0.1 g/cm3
- Soluble in DMSO at 100 mg/mL
- For research use only
- Available documentation includes data sheet, SDS, COA, HNMR, and MS
![eMolecules bis-PEG2-endo-BCN | Broadpharm | 1476737-97-9 | MFCD19705423 | 500.636 | C28H40N2O6 | 97.000 | O=C(NCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 50mg | 340377180](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1737768.jpg-250.jpg)
eMolecules bis-PEG2-endo-BCN | Broadpharm | 1476737-97-9 | MFCD19705423 | 500.636 | C28H40N2O6 | 97.000 | O=C(NCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 50mg | 340377180
bis-PEG2-endo-BCN | Broadpharm | 1476737-97-9 | MFCD19705423 | 500.636 | C28H40N2O6 | 97.000 | O=C(NCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 50mg | 340377180
Medchemexpress LLC m-PEG-DMG | 1019000-64-6 | ≥98.0% | 2000 Da (average) | (C2H4O)nC36H73NO5 | 5 MG
m-PEG-DMG (MW 2000) is a methoxy-terminated polyethylene glycol lipid with a dimyristoyl glycerol anchor and an average molecular weight of 2,000 Da. It is intended for incorporation into liposomes and lipid nanoparticles to provide a PEG corona that enhances stability and circulation time in drug delivery research.
- Enhances colloidal stability and circulation time
- Reduces protein adsorption and opsonization
- Facilitates PEGylation of liposome and nanoparticle surfaces
- Supplied in lab-scale quantities suitable for formulation studies
- High purity for reproducible formulation performance
eMolecules Aminooxy-PEG3-bromide | 1895922-73-2 | MFCD29764339 | 1g
Broadpharm | Aminooxy-PEG3-bromide | 1g | 311074478 | BP-23143 | 98.000 | 1895922-73-2 | MFCD29764339 | 272.139 | C8H18BrNO4
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